Henry Ford Health System

Cancer - Breast

Study Title      Principal Investigator
CTSU: Program for the assessment of Clinical Cancer Tests (PACCT-1): Trial Assessing Individualized Options for Treatment: The TRAILORx Trial      Robert Chapman, MD
NSABP B-51/RTOG 1304: A Randomized Phase 3 Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy who Convert to Pathologically Negative Axill      Thomas Doyle, MD
NSABP B-47: A Randomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles) of Docetaxel Plus Cyclophosphamide or Four Cycles of Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel to Chemotherapy Plus Trastuzumab      Thomas Doyle, MD
Phase 2 Randomized Study of Whole Brain Radiotherapy in Combination with Concurrent Lapatinib in Patients With Brain Metastasis From HER2- Positive Breast Cancer: A Collaborative Study of RTOG and KROG      Walker, Eleanor, M.D.

Cancer - Breast/ Gastro/ Lung/ Lymphoma/ Thyroid

Study Title      Principal Investigator
SWOG 0711: Phase I Pharmacokinetic Study of Dasatinib (BMS-354825) (NSC-732517, IND-73969) in Patients with Advanced Malignancies and Varying Levels of Liver Dysfunction      Chapman, Robert, M.D.

Cancer - Breast/ Genitourinary Prostate/ Lung

Study Title      Principal Investigator
RTOG 0631: Phase II/III Study of Image-Guided Radiosurgery/SBRT for Localized Spine Metastasis      Walker, Eleanor, M.D.

Cancer - Gastro

Study Title      Principal Investigator
RTOG 0848: A Phase III Trial Evaluating Both Erlotinib and Chemoradiation as Adjuvant Treatment for Patients with Resected Head of Pancreas Adenocarcinoma      Walker, Eleanor, M.D.

Cancer - Gastro/ Colorectal

Study Title      Principal Investigator
CTSU N1048: Phase 2/3 Trial of Neoadjuvant FOLFOX w. Selective Use of Combined Modality Chemotherapy v. Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection w. Total Mesorectal Excision      Chapman, Robert, M.D.

Cancer - Gastro/ Esophageal

Study Title      Principal Investigator
RTOG 1221: Randomized Phase II Trial of Transoral Endoscopic Head And Neck Surgery Followed by Risk-based IMRT and Weekly Cisplatin Versus IMRT and Weekly Cisplatin for HPV Negative Oropharynx Cancer      Eleanor Walker, MD
SWOG 1201: A Randomized Phase II Pilot Study Prospectively Evaluating Treatment for Patients Based on ERCC1 (Excision Repair Crossed-Complementing 1) for Advanced/Metastatic Esophageal, Gastric, or Gastroesophageal Junction (GEJ) Cancer      Robert Chapman, MD
Phase III Trial of Radiotherapy Plus Cetuximab Versus Chemoradiotherapy in HPV-Associated Oropharynx Cancer      Walker, Eleanor, M.D.
RTOG 1010: A Phase III Trial Evaluating the Addition of Trastuzumab to Trimodality Treatment of HER2-Overexpressing Esophageal Adenocarcinoma      Walker, Eleanor, M.D.

Cancer - Genitourinary/ Prostate

Study Title      Principal Investigator
A031201: Phase III Trial of Enzalutamide versus Enzalutamide, Abiraterone and Prednisone For Castration Resistant Metastatic Prostate Cancer      Chapman, Robert, M.D.
RTOG 0815: A Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy With or Without Short-Term Androgen Deprivation Therapy for Patients With Intermediate-Risk Prostate Cancer      Walker, Eleanor, M.D.
RTOG 0924: Androgen Deprivation Therapy and High Dose Radiotherapy with or without Whole-pelvic Radiotherapy in Unfavorable Intermediate or Favorable High Risk Prostate Cancer: A Phase III Randomized Trial      Walker, Eleanor, M.D.
RTOG 0534: A Phase III Trial of Short Term Androgen Depriviation With Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPORT) in Prostate Cancer With a Rising PSA After Radical Prostatectomy      Walker, Eleanor, M.D.

Cancer - Genitourinary/ Prostate/ Kidney

Study Title      Principal Investigator
A031203: Randomized Phase II Study Comparing Cabozantinib (NSC #761968 and IND #116059) With Commercially Supplied Sunitinib in Patients with Previously Untreated Locally Advanced or Metastatic Renal Cell Carcinoma      Chapman, Robert, M.D.

Cancer - Head and Neck

Study Title      Principal Investigator
E3311: Phase II Randomized Trial of Transoral Surgical Resection followed by Low-dose or Standard-dose IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer      Chapman, Robert, M.D.

Cancer - Lung

Study Title      Principal Investigator
SWOG 0819: A Randomized, Phase III Study Comparing Carboplatin/Paclitaxel or Carboplatin/Paclitaxel/Bevacizumab with or without Concurrent Cetuximab in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC).      Chapman, Robert, M.D.
E2511: Phase I and Randomized Phase II Double Blind Clinical Trial of Cisplatin and Etoposide in Combination With Veliparib (ABT-888) or Placebo as Frontline Therapy for Extensive Stage Small Cell Lung Cancer      Rybkin, Igor, M.D.
SWOG 1206: A Dose Finding Study Followed by Phase II Randomized, Placebo-Controlled Study of Veliparib (ABT-888) Added to Chemoradiotherapy with Carboplatin and Paclitaxel for Unresectable Stage III Non-Small Cell Lung Cancer      Wang, Ding, M.D.

Cancer - Melanoma

Study Title      Principal Investigator
E1609 A Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Therapy Versus High-Dose Interferon a-2b for Resected High-Risk Melanoma      Chapman, Robert, M.D.

Cancer - Pancreatic

Study Title      Principal Investigator
A Phase III Study of Chemotherapy and Chemoradiotherapy With or Without HyperAcute┬« - Pancreas (ALGENPANTUCEL-L) Immunotherapy      McFarlin, Kellie, M.D.
A Phase III Trival Evaluating Both Erlotinib and Chemoradiation as Adjuvant Treatment for Patients with Resected Head of Pancreas Adenocarcinoma      Walker, Eleanor, M.D.

Cancer - Thyroid

Study Title      Principal Investigator
An International, Randomized, Double-Blinded, Phase III Efficacy Study of XL 184 versus Placebo in Subjects with Unresectable, Locally Advanced, or Metastatic Medullary Thyroid Cancer      Ali, Haythem, M.D.