L. Keoki Williams M.D. M.P.H.

williams k
Investigator
Phone: (313) 874-5454
Fax: (313) 874-7137

Recent publications

Habib ZA, Havstad SL, Wells K, Divine G, Pladevall M, Williams LK. Thiazolidinedione use and the longitudinal risk of fractures in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2010 Feb;95(2):592-600.

Kumar R,* Seibold MA,* Aldrich MC,* Williams LK,* Reiner AP, Colangelo L, Galanter J, Gignoux C, Hu D, Sen S, Choudhry S, Peterson EL, Rodriguez-Santana J, Rodriguez-Cintron W, Nalls MA, Leak TS, O'Meara E, Meibohm B, Kritchevsky SB, Li R, Harris TB, Nickerson DA, Fornage M, Enright P, Ziv E, Smith LJ, Liu K, Burchard EG. Genetic Ancestry in Lung-Function Predictions. N Engl J Med. 2010 Jul 22;363(4):321-30. [*denotes equal author contribution to the article]

Pladevall M, Brotons C, Gabriel R, Arnau A, Suarez C, de la Figuera M, Marquez E, Coca A, Sobrino J, Divine G, Heisler M, Williams LK, Writing Committee on behalf of the COM99 Study Group. Multicenter Cluster-Randomized Trial of a Multifactorial Intervention to Improve Antihypertensive Medication Adherence and Blood Pressure Control Among Patients at High Cardiovascular Risk (The COM99 Study). Circulation. 2010 Sep 21;122(12):1183-1191.

Jin YD, Hu EL, Peterson EL, Eng C, Levin AM, Wells K, Beckman K, Kumar R, Seibold MA, Karungi G, Zoratti A, Gaggin J, Campbell J, Galanter J, Chapela R, Rodriguez-Santana JR, Watson HG, Meade K, Lenoir M, Rodriguez-Cintron W, Avilla PC, Lanfear DE, Burchard EG,Williams LK. Dual-specificity phosphatase 1 as a pharmacogenetic modifier of inhaled steroid response among asthmatic patients. J Allergy Clin Immunol. 2010 Sep;126(3):618-625.

Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Levin AM, Mathias RA, Hancock DB, Baurley JW, Eng C, Stern DA, Celedón JC, Rafaels N, Capurso D, Conti DV, Roth LA, Soto-Quiros M, Togias A, Li X, Myers RA, Romieu I, Van Den Berg DJ, Hu D, Hansel NN, Hernandez RD, Israel E, Salam MT, Galanter J, Avila PC, Avila L, Rodriquez-Santana JR, Chapela R, Rodriguez-Cintron W, Diette GB, Adkinson NF, Abel RA, Ross KD, Shi M, Faruque MU, Dunston GM, Watson HR, Mantese VJ, Ezurum SC, Liang L, Ruczinski I, Ford JG, Huntsman S, Chung KF, Vora H, Li X, Calhoun WJ, Castro M, Sienra-Monge JJ, del Rio-Navarro B, Deichmann KA, Heinzmann A, Wenzel SE, Busse WW, Gern JE, Lemanske RF Jr, Beaty TH, Bleecker ER, Raby BA, Meyers DA, London SJ; Mexico City Childhood Asthma Study (MCAAS), Gilliland FD; Children's Health Study (CHS) and HARBORS study, Burchard EG; Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Latino Americans (GALA2) and Study of African Americans, Asthma, Genes & Environments (SAGE), Martinez FD; Childhood Asthma Research and Education (CARE) Network, Weiss ST; Childhood Asthma Management Program (CAMP), Williams LK; Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE), Barnes KC; Genetic Research on Asthma in African Diaspora (GRAAD) Study, Ober C, Nicolae DL. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet. 2011 Jul 31;43(9):887-92.

Wells KE, Peterson EL, Ahmedani BK, Severson RK, Gleason-Comstock J, Williams LK. The relationship between combination inhaled corticosteroid and long-acting β-agonist use and severe asthma exacerbations in a diverse population. J Allergy Clin Immunol. 2012 May;129(5):1274-1279.

Levin AM, Mathias RA, Huang L, Roth LA, Daley D, Myers RA, Himes BE, Romieu I, Yang M, Eng C, Park JE, Zoratti K, Gignoux CR, Torgerson DG, Galanter JM, Huntsman S, Nguyen EA, Becker AB, Chan-Yeung M, Kozyrskyj AL, Kwok PY, Gilliland FD, Gauderman WJ, Bleecker ER, Raby BA, Meyers DA, London SJ, Martinez FD, Weiss ST, Burchard EG, Nicolae DL, Ober C, Barnes KC, Williams LK. A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. J Allergy Clin Immunol. 2013 [Epub ahead of print]

Hayek S, Escaro FC, Sattar A, Gamalski S, Wells KE, Divine G, Ahmedani BK, Lanfear DE, Pladevall M, Williams LK. Effect of Ezetimibe on Major Atherosclerotic Disease Events and All-Cause Mortality. Am J Cardiol. 2013 [Epub ahead of print]

Biography

Dr. Williams is both a practicing internist and senior research scientist. He has an appointment in the Department of Medicine and is the associate director of the Center for Health Policy and Health Services Research at Henry Ford Health System.

Dr. Williams graduated cum laude in both research and academics from the University of Michigan Medical School and is a former HHMI-NIH Research Scholar. He completed a residency in internal medicine at the Brigham and Women's Hospital in Boston. Afterward, he served as an officer in the Epidemic Intelligence Service at the U.S. Centers for Disease Control and Prevention. He also completed a fellowship in General Medicine and was a National Research Service Award recipient.

His current research interests include genetic epidemiology, pharmacogenomics, and pharmacoepidemiology (including patient adherence to medicine). His primary disease interests include asthma and associated allergic conditions, diabetes, cardiovascular disease, and mental health disorders. These broad interests are reflected in his four separate independent investigator (R01) awards through three different institutes (NIAID, NHLBI, and NIDDK) at the U.S. National Institutes of Health. He is also the recipient of an Early Excellence Award from the American Asthma Foundation.