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Research Opportunities

  • All fellows are required to participate in on-going or original research projects to graduate from the program.
    • The research faculty, as well as the physicians, serve as mentors for these projects.
    • Presentations at national meetings and manuscript submissions are anticipated from these activities.
    • All presenting fellows attend the annual American Academy of Sleep Medicine (AASM) and Associated Professional Sleep Societies LLC (APSS) meeting.
  • Research time of ½ day a week will be given to fellows if more dedicated research time is needed (IRB approved research, metanalysis/review article, or publication of a case report in peer reviewed journal)
  • Fellows also participate in Section Quality Assurance projects.

Past Research Projects

SLEEP MEDICINE PUBLICATIONS 2022:

  1. Balikji J, Hoogbergen MM, Garssen J, Roth T, and Verster JC. Insomnia Complaints and Perceived Immune Fitness in Young Adults with and without Self-Reported Impaired Wound Healing. Medicina (Kaunas) 2022; 58(8). PMID: 36013516.
  2. Berro LF, and Roehrs T. Catching up on sleep: Recent evidence on the role of sleep in substance use disorders. Pharmacol Biochem Behav 2022; 213:173330. PMID: 34995638.
  3. Cheng P, Kalmbach DA, Hsieh HF, Castelan AC, Sagong C, and Drake CL. Improved resilience following digital cognitive behavioral therapy for insomnia protects against insomnia and depression one year later. Psychol Med 2022;1-11. PMID: 35257648.
  4. Dabaja F, Skiba V, and Palmer W. CAN THE INTERFACE UTILIZED IN CONTINUOUS POSITIVE AIRWAY PRESSURE THERAPY SIGNIFICANTLY ALTER THE APNEA-HYPOPNEA INDEX IN CERTAIN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA? Sleep 2022; 45(SUPPL 1):A356
  5. Dahl T, Zammit G, Ahmad M, Rosenberg R, Chen LB, and Roth T. Efficacy of the triple-combination SM-1 in a 5-h phase advance transient insomnia model. Sleep Biol Rhythms 2022; 20(1):47-52. PMID: Not assigned.
  6. Drake CL, Kalmbach DA, Cheng P, Ahmedani BK, Peterson EL, Joseph CLM, Roth T, Kidwell KM, and Sagong C. Sleep to Reduce Incident Depression Effectively (STRIDE): study protocol for a randomized controlled trial comparing stepped-care cognitive-behavioral therapy for insomnia versus sleep education control to prevent major depression. Trials 2022; 23(1):967. PMID: 36457045.
  7. Hadid R, and Skiba V. Board Review: Not so fast! Home sleep apnea testing. J Clin Sleep Med 2022; 19(1):207-208. PMID: 36148626.
  8. Haggerty D, Contreras DA, Carter A, Drake C, and Tucker RM. Sleep Education for Everyone Program (SLEEP) Results in Sustained Improvements in Sleep Outcomes at Six Months. Behav Sleep Med 2022;1-7. PMID: 36377788.
  9. Johnson DA, Reiss B, Cheng P, and Jackson CL. Understanding the role of structural racism in sleep disparities: a call to action and methodological considerations. Sleep 2022; 45(10). PMID: 35999030.
  10. Kalmbach DA. The emerging role of prenatal insomnia therapy in the prevention of perinatal depression and anxiety. Sleep 2022; 45(5). PMID: 35554574.
  11. Kalmbach DA, and Cheng P. Embracing telemedicine and digital delivery of cognitive behavioral therapy for insomnia: Where do we come from and where are we going? Sleep 2022; Epub ahead of print. PMID: 36455233.
  12. Kalmbach DA, Cheng P, Ahmedani BK, Peterson EL, Reffi AN, Sagong C, Seymour GM, Ruprich MK, and Drake CL. Cognitive-behavioral therapy for insomnia prevents and alleviates suicidal ideation: Insomnia remission is a suicidolytic mechanism. Sleep 2022; 45(12). PMID: 36242607.
  13. Kalmbach DA, Cheng P, Reffi AN, Seymour GM, Ruprich MK, Bazan LF, Pitts DS, Walch O, and Drake CL. Racial disparities in treatment engagement and outcomes in digital cognitive behavioral therapy for insomnia among pregnant women. Sleep Health 2022; Epub ahead of print. PMID: 36456448.
  14. Kalmbach DA, Cheng P, Roth A, Roth T, Swanson LM, O'Brien LM, Fresco DM, Harb NC, Cuamatzi-Castelan AS, Reffi AN, and Drake CL. DSM-5 insomnia disorder in pregnancy: associations with depression, suicidal ideation, and cognitive and somatic arousal, and identifying clinical cutoffs for detection. Sleep Adv 2022; 3(1):zpac006. PMID: 35391758.
  15. Kalmbach DA, Fernandez-Mendoza J, and Drake CL. Stress and sleep reactivity increase risk for insomnia: Highlighting the dynamic interplay between sleep-wake regulation and stress responsivity. Sleep 2022; Epub ahead of print. PMID: 36507774.
  16. Kushida CA, Roth T, Shapiro CM, Roy A, Rosenberg R, Ajayi AO, Seiden D, and Gudeman J. Response to: Once-nightly sodium oxybate (FT218) in the treatment of narcolepsy: a letter to the editor commenting on the recent publication by C. Kushida et al. Sleep 2022; 45(6). PMID: 35695179.
  17. Liang E, Dolan JL, Morris ED, Vono J, Bazan LF, Lu M, and Glide-Hurst CK. Application of Continuous Positive Airway Pressure for Thoracic Respiratory Motion Management: An Assessment in a Magnetic Resonance Imaging-Guided Radiation Therapy Environment. Adv Radiat Oncol 2022; 7(3):100889. PMID: 35198838.
  18. Mahr G, and Drake CL. Singing in tune: Carl Jung and The Red Book. Sleep Health 2022; 8(4):347-349. PMID: 35831228.
  19. Mignot E, Mayleben D, Fietze I, Leger D, Zammit G, Bassetti CLA, Pain S, Kinter DS, and Roth T. Safety and efficacy of daridorexant in patients with insomnia disorder: results from two multicentre, randomised, double-blind, placebo-controlled, phase 3 trials. Lancet Neurol 2022; 21(2):125-139. PMID: 35065036.
  20. Moreno JP, Hannay KM, Walch O, Dadabhoy H, Christian J, Puyau M, El-Mubasher A, Bacha F, Grant SR, Park RJ, and Cheng P. Estimating circadian phase in elementary school children: leveraging advances in physiologically informed models of circadian entrainment and wearable devices. Sleep 2022; 45(6). PMID: 35275213.
  21. Ochoa-Lácar J, Singh M, Bird SP, Charest J, Huyghe T, and Calleja-González J. How Sleep Affects Recovery and Performance in Basketball: A Systematic Review. Brain Sci 2022; 12(11). PMID: 36421894.
  22. Plawecki A, Tripathi N, Tovar Torres M, and Yaremchuk K. Interference With Implanted Upper Airway Stimulation Device by Phones With Magnet Technology. Laryngoscope 2022; 132(12):2513-2515. PMID: 35975894.
  23. Reffi AN, Cheng P, Kalmbach DA, Jovanovic T, Norrholm SD, Roth T, and Drake CL. Is a blunted cortisol response to stress a premorbid risk for insomnia? Psychoneuroendocrinology 2022; 144:105873. PMID: 35905512.
  24. Reffi AN, Drake CL, Kalmbach DA, Jovanovic T, Norrholm SD, Roth T, Casement MD, and Cheng P. Pre-pandemic sleep reactivity prospectively predicts distress during the COVID-19 pandemic: The protective effect of insomnia treatment. J Sleep Res 2022;e13709. PMID: 36053867.
  25. Reffi AN, Kalmbach DA, Cheng P, Jovanovic T, Norrholm SD, Sexton MB, Mahr G, Arnett L, Seymour G, and Drake CL. Sleep reactivity as a potential pathway from childhood abuse to adult insomnia. Sleep Med 2022; 94:70-75. PMID: 35504109.
  26. Rehman A, Drake CL, Shiramizu V, and Fleming L. Sleep reactivity predicts insomnia in patients diagnosed with breast cancer. J Clin Sleep Med 2022; 18(11):2597-2604. PMID: 35912701.
  27. Robbins R, Quan SF, Buysse D, Weaver MD, Walker MP, Drake CL, Monten K, Barger LK, Rajaratnam SMW, Roth T, and Czeisler CA. A Nationally Representative Survey Assessing Restorative Sleep in US Adults. Front Sleep 2022; 1. PMID: 36042946.
  28. Rogers J, Gong X, Byars-Winston A, McDaniels M, Thayer-Hart N, Cheng P, Diggs-Andrews K, Martínez-Hernández KJ, and Pfund C. Comparing the Outcomes of Face-to-Face and Synchronous Online Research Mentor Training Using Propensity Score Matching. CBE Life Sci Educ 2022; 21(4):ar62. PMID: 36112621.
  29. Roth T, Dauvilliers Y, Thorpy MJ, Kushida C, Corser BC, Bogan R, Rosenberg R, Dubow J, and Seiden D. Effect of FT218, a Once-Nightly Sodium Oxybate Formulation, on Disrupted Nighttime Sleep in Patients with Narcolepsy: Results from the Randomized Phase III REST-ON Trial. CNS Drugs 2022; 36(4):377-387. PMID: 35380374.
  30. Roth T, Rosenberg R, Morin CM, Yardley J, Pinner K, Perdomo C, Atkins N, Jr., Pappadopulos E, Malhotra M, and Moline M. Impact of lemborexant treatment on insomnia severity: analyses from a 12-month study of adults with insomnia disorder. Sleep Med 2022; 90:249-257. PMID: 35220140.
  31. Santarossa S, Rapp A, Sardinas S, Hussein J, Ramirez A, Cassidy-Bushrow AE, Cheng P, and Yu E. Understanding the #longCOVID and #longhaulers Conversation on Twitter: Multimethod Study. JMIR Infodemiology 2022; 2(1):e31259. PMID: 35229074.
  32. Skiba V, and McLellan B. Safe use of donated positive airway pressure devices to increase access to treatment for obstructive sleep apnea: a clinical outreach program. J Clin Sleep Med 2022; 18(5):1455-1457. PMID: 35484640.
  33. Thiesse L, Staner L, Fuchs G, Kirscher D, Dehouck V, Roth T, Schaffhauser JY, Saoud JB, and Viola AU. Performance of Somno-Art Software compared to polysomnography interscorer variability: A multi-center study. Sleep Med 2022; 96:14-19. PMID: 35576829.
  34. Walker JL, Vargas I, Drake CL, Ellis JG, Muench A, and Perlis ML. The Natural History of Insomnia: High Sleep Reactivity Interacts with Greater Life Stress to Predict the Onset of Acute Insomnia. Sleep 2022; 45(9). PMID: 35776964.
  35. Wickwire EM, Abdelwadoud M, Collen J, Edwards H, Labra C, Capaldi VF, Williams SG, Manber R, Assefa SZ, Drake CL, Albrecht JS, Bevan J, Mahoney A, Tatum ED, Pierre E, M]antua J, Grandner MA, and Mullins CD. Active Duty Service Members, Primary Managers, and Administrators' Perspectives on a Novel Sleep Telehealth Management Platform in the U.S. Military Healthcare System. Mil Med 2022; 187(9-10):e1201-e1208. PMID: 35089344

SLEEP MEDICINE ABSTRACTS 2022:

  1. Cheng P, Casement M, Kalmbach D, Castelan AC, and Drake C. Digital Cognitive Behavioral Therapy for Insomnia Promotes Resilience During the Coronavirus Disease 19 (COVID-19) Pandemic. Sleep Med 2022; 100:S114.
  2. Cheng P, Casement M, Kalmbach D, Hsieh HF, and Drake C. Insomnia and stress: Moving beyond diathesis stress. J Sleep Research 2022; 31.
  3. Cheng P, Kalmbach D, Hsieh HF, Castelan AC, Sagong C, and Drake C. IMPROVED RESILIENCE FOLLOWING COGNITIVE BEHAVIORAL THERAPY FOR INSOMNIA MEDIATES TREATMENT OUTCOMES AND PROTECTS AGAINST LONG-TERM INSOMNIA AND DEPRESSION. Sleep 2022; 45(SUPPL 1):A196-A197.
  4. Cheng P, Kalmbach D, Sultan Z, Fellman-Couture C, and Drake C. COMPARATIVE EFFICACY OF DIGITAL CBT-I VERSUS STEPPED-CARE CBT-I TO PREVENT DEPRESSION. Sleep 2022; 45(SUPPL 1):A290-A291.
  5. Cheng P, Santarossa S, Kalmbach D, and Drake C. P689. Improving Treatment Effectiveness in Marginalized Individuals: Facilitators and Barriers to Digital Cognitive Behavioral Therapy for Insomnia. Biol Psychiatry 2022; 91(9):S369.
  6. Dauvilliers Y, Roth T, Bogan R, Thorpy M, Morse AM, Roy A, Seiden D, Dubow J, and Gudeman J. Efficacy of Once-Nightly Sodium Oxybate (ON-SXB; FT218) By Narcolepsy Type: Post-hoc Analyses From the REST-ON Trial. Sleep Med 2022; 100:S157.
  7. Dauvilliers Y, Roth T, Bogan R, Thorpy MJ, Morse AM, Roy A, Seiden D, Dubow J, and Gudeman J. Efficacy of Once-Nightly Sodium Oxybate (ONSXB; FT218) by Narcolepsy Type: Post-Hoc Analyses from the REST-ON Trial. Ann Neurol 2022; 92:S222.
  8. Drake C, Yardley J, Pinner K, and Moline M. SUBJECTIVE RATINGS OF MEDICATION STRENGTH OVER 6 MONTHS IN ELDERLY SUBJECTS WITH MODERATE OR SEVERE INSOMNIA TREATED WITH LEMBOREXANT. Am J Geriatr Psychiatry 2022; 30(4):S74-S75.
  9. Drake C, Yardley J, Pinner K, and Moline M. Subjective ratings of medication strength of lemborexant over 6 months in subjects with moderate or severe insomnia. J Sleep Research 2022; 31.
  10. Drake C, Yardley J, Pinner K, Perdomo C, and Moline M. LONG-TERM PERCEPTION OF MEDICATION EFFECTIVENESS IN ELDERLY SUBJECTS WITH INSOMNIA RECEIVING LEMBOREXANT FOR UP TO 12 MONTHS. Am J Geriatr Psychiatry 2022; 30(4):S74-S74. 261
  11. Drake C, Yardley J, Pinner K, Perdomo C, and Moline M. Evaluation of Long-term Perception of Medication Effectiveness: Results from Subjects Receiving Lemborexant for up to 12 Months. Sleep Med 2022; 100:S120.
  12. Jaziri M, Palmer W, and Tovar M. Positional therapy in a patient with refractory treatment-emergent central sleep apnea. Sleep Med 2022; 100:S266-S267.
  13. Jaziri M, Smith N, Bazan L, Pitts D, and Kalmbach D. IMPROVING DETECTION OF OBSTRUCTIVE SLEEP APNEA IN PREGNANT WOMEN USING A SIX-POINT SCREENING TOOL. Sleep 2022; 45(SUPPL 1):A305-A306.
  14. Kalmbach D, Cheng P, Pitts D, O'Brien L, Seymour G, Cuamatzi-Castelan A, Bazan L, and Drake C. RACIAL DISPARITIES IN PATIENT OUTCOMES AND TREATMENT ENGAGEMENT IN COGNITIVE BEHAVIORAL THERAPY FOR INSOMNIA AMONG PREGNANT WOMEN. Sleep 2022; 45(SUPPL 1):A198-A199.
  15. Kalmbach D, Cheng P, Reffi A, Ahmedani B, Peterson E, Seymour G, Sagong C, Sultan Z, and Drake C. COGNITIVE-BEHAVIORAL THERAPY FOR INSOMNIA ALLEVIATES AND PREVENTS SUICIDAL IDEATION. Sleep 2022; 45(SUPPL 1):A299.
  16. Koshorek G, Parashar V, Roth T, and Roehrs T. BASELINE SLEEP DISTURBANCE AND INABILITY TO DISCONTINUE CHRONIC HYPNOTIC USE. Sleep 2022; 45(SUPPL 1):A204-A205.
  17. Kushida C, Roth T, Thorpy M, Seiden D, Dubow J, and Gudeman J. Efficacy of FT218, a Once-Nightly Sodium Oxybate Formulation, in Patients With Narcolepsy: Post-hoc Sensitivity Analyses From the REST-ON Trial. Sleep Med 2022; 100:S156-S157.
  18. Melikyan D, Santarossa S, Sagong C, Sultan Z, Drake C, and Cheng P. PATIENT PERSPECTIVES ON FACILITATORS AND BARRIERS TO ENGAGEMENT WITH DIGITAL CBT-I. Sleep 2022; 45(SUPPL 1):A205.
  19. Miller C, Magill N, Emsley R, Henry A, Carl J, McClendon J, James C, Luik A, Freeman D, Sheaves B, O'Donnell M, McGrath E, Gregory A, Denis D, Kyle S, Cheng P, Felder J, Kalmbach D, Drake C, Barnes C, and Espie C. What moderates CBT for insomnia? Findings from a participant-level analysis of 8,549 individuals in 12 randomised controlled trials of digital CBT (Sleepio). J Sleep Research 2022; 31.
  20. Moline M, Roth T, Pinner K, Yardley J, Pappadopulos E, and Malhotra M. CORRELATIONS BETWEEN SLEEP PARAMETERS AND ISI TOTAL SCORE IN SUBJECTS WITH MODERATE TO SEVERE INSOMNIA TREATED WITH LEMBOREXANT. Sleep 2022; 45(SUPPL 1):A199.
  21. Parashar V, Koshorek G, Roth T, and Roehrs T. SLEEP ASSESSED BY ACTIGRAPHY DURING DISCONTINUATION OF CHRONIC HYPNOTIC USE. Sleep 2022; 45(SUPPL 1):A205. 262
  22. Pinner K, Drake C, Yardley J, Perdomo C, and Moline M. Self-reported perceptions of medication effectiveness in subjects receiving lemborexant for up to 12 months. J Sleep Research 2022; 31.
  23. Ravi A, Bryans H, Ruprich M, Burgeess H, Roth T, Drake C, and Cheng P. SLEEP TIME AND RISK TAKING BEHAVIOUR IN NIGHT SHIFT-WORKERS. Sleep 2022; 45(SUPPL 1):A151.
  24. Reffi A, Cheng P, Kalmbach D, Sultan Z, and Drake C. SLEEP REACTIVITY PROSPECTIVELY PREDICTS DISTRESS REACTIONS TO THE COVID-19 PANDEMIC 3-4 YEARS LATER. Sleep 2022; 45(SUPPL 1):A107.
  25. Roth T, Moline M, Pinner K, Yardley J, Pappadopulos E, and Malhotra M. SUBJECTIVE SLEEP OUTCOMES WITH LEMBOREXANT AMONG SUBJECTS WITH INSOMNIA AND CLINICALLY MEANINGFUL DECREASES ON THE INSOMNIA SEVERITY INDEX. Sleep 2022; 45(SUPPL 1):A195-A196.
  26. Roth T, Yardley J, Pinner K, Kumar D, Cheng JY, and Moline M. The incidence of abnormal dreams and nightmares in adults with insomnia treated with lemborexant: results from two Phase 3 studies. Sleep Med 2022; 100:S142.
  27. Roth T, Zammit G, Kumar D, Pappadopulos E, and Moline M. Lemborexant versus Zolpidem: An Assessment of Wake Bouts in Adults with Insomnia. Sleep Med 2022; 100:S128-S129.
  28. Thorpy M, Dauvilliers Y, Roth T, Morse AM, Roy A, Bogan R, Seiden D, Dubow J, and Gudeman J. Efficacy of Once-Nightly Sodium Oxybate (ON-SXB; FT218) Across Stimulant Use Subgroups: Post-hoc Analyses From the REST-ON Trial. Sleep Med 2022; 100:S157.
  29. Thorpy M, Roth T, Kushida C, Seiden D, Dubow J, and Gudeman J. Efficacy of Once-nightly Sodium Oxybate (ON-SXB; FT218) for Excessive Daytime Sleepiness and Cataplexy: Post-hoc Number Needed to Treat and Effect Size Analyses From REST-ON. Sleep Med 2022; 100:S157-S158.
  30. Thorpy MJ, Roth T, Kushida CA, Seiden D, Dubow J, and Gudeman J. Efficacy of Once-Nightly Sodium Oxybate (ONSXB; FT218) for Excessive Daytime Sleepiness and Cataplexy: Post-Hoc Number Needed to Treat and Effect Size Analyses from REST-ON. Ann Neurol 2022; 92:S223.
  31. Viola A, Thiesse L, Staner L, Fuchs G, Kirscher D, Dehouck V, Schaffhauser JY, Roth T, Saoud J, and Luthringer R. Inter-scorer reliability between Somno-Art Software and 5 sleep centers. J Sleep Research 2022; 31.
  32. Viola A, Thiesse L, Staner L, Fuchs G, Kirscher D, Roth T, Schaffhauser JY, Saoud J, and Luthringer R. Comparison of the paroxetine's effect on the sleep parameters measurements extracted by polysomnography vs somno-art in depressed patients. J Sleep Research 2022; 31. 263
  33. Zammit G, Roth T, Kumar D, Perdomo C, and Moline M. Impact of Lemborexant Versus Placebo and Zolpidem on REM Sleep Duration by Quarter-of-the-Night Intervals in Older Adults with Insomnia Disorder. Sleep Med 2022; 100:S123

There are currently ongoing Research Projects in the areas:

  • Pharmacology of sleep
  • Long-term effect of sleep medications
  • Insomnia
  • Hypersomnia disorders
  • Effects of Shift work
  • Pregnancy and sleep disorders
Information for Applicants
Interested in applying to one of our programs, call (800) 436-7936.
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