RTOG 0834/EORTC26053_22054, Phase III trial on concurrent and adjuvant temozolomide chemotherapy in non-1p/19q deleted anaplastic glioma. The CANTON Intergroup trial.
December 17, 2009
Cancer - Brain
Histologically confirmed newly diagnosed anaplastic oligodendroglioma, anaplastic oligoastrocytoma or anaplastic astrocytoma by local diagnosis and absence of combined 1p/19q loss; available tumor material for central 1p/19q assessment, central MGMT promoter methaylation and central pathology review; previous surgery for a low grade tumor is allowed, provided histological confirmation of an anaplastic tumor is present at the time of progression.