Yalei Chen

Yalei Chen, PhD

medical group

Specialties: Research

Services: Biostatistics

Board Certification and Education

Education

  • Pennsylvania State University, Biology, PA, 2014

About Me

Biographical Statement:
As a biostatistician in Public Health Sciences, my research utilizes bioinformatic tools, imaging analysis and statistical modeling to discover biological changes associated with disease. During my PhD, I received multi-disciplinary training in biology, microscopic imaging, engineering and statistics.

While studying molecular mechanisms of cancer using single molecular imaging. I developed a step-finding algorithm to measure molecular copies, and I used similar commonly used algorithms in segmenting DNA copy numbers from sequencing and SNP array data.

Since joining HFHS, I have been working on analyzing genomic, epigenomic and imaging data in studies covering diseases, such as cancer, sarcoidosis and preterm birth. I have developed an improved Generalized Estimating Equation method to identify gene-environment interaction while incorporating sample correlation in admixed populations.

In particular, I have been working closely with my primary mentor Dr. Rybicki in analyzing immunohistochemical staining of prostate benign biopsy. I have built multiple image processing pipelines for semi-automated quantification of IHC stains. More importantly, these experiences also introduced me to prostate pathology and steered my interest in computationally characterizing histological changes in prostate tissues.

Research Interests:

  • Computational imaging analysis for cancer diagnosis, treatment and prognosis
  • Quantitative genomic analysis
  • Statistical method development
  • Digital pathology

Awards and Honors:

  • Henry Ford Cancer Institute Travel Award for AACR annual meeting (2017)
  • People's Scholarship in Scientific Research, Nanjing University (2007)
  • People's Scholarship in Scientific Research, Nanjing University (2006)

Languages

English, Chinese

Gender

Male

Locations

Public Health Sciences
1 Ford Place
3E
Detroit, MI 48202

Hospital Privileges

  • Henry Ford Hospital

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