Hongsheng Gui

Hongsheng Gui, PhD

medical group

Specialties: Research

Board Certification and Education


  • University of Hong Kong, 2013

About Me

Biographical Statement

Dr. Gui is a a statistical geneticist in the field of complex disease research, and with particular interest in mental health. He received training from both psychiatric genetics and genomic science, and has been working on multi-Omics (e.g., genomics, transcriptomics, and phenomics) projects for multiple diseases. Dr. Gui's research focuses on identifying genetic biomarkers and gene x environment interactions involved in the development of neuropsychiatric diseases (e.g., severe mental illnesses, and substance use disorders). He is interested in reducing health disparity across diverse populations through precision psychiatry. Dr. Gui is currently working on following projects:

  • identify genetic and clinical risk factors for opioid use disorder (OUD) in diverse populations and apply an ancestry-tailored risk component to polygenic risk scores
  • investigate adverse drug reactions and treatment response during medication-assisted treatment for major depressive disorder and OUD
  • reveal correlation and causation relationship between OUD and suicidal attempt using multivariate statistical tools.


English, Chinese




Center for Health Services Research
Ste 3 A
One Ford Place
Detroit, MI 48202

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