Hongsheng Gui, PhD

Biographical Statement

Hongsheng Gui, PhD, is a statistical geneticist, assistant scientist, and principal investigator at Henry Ford Health whose research focuses on the genetic and molecular basis of complex diseases, with particular expertise in psychiatric genetics and precision medicine. He earned his doctorate from the University of Hong Kong, where he received interdisciplinary training in psychiatric genetics and genomic science.

Dr. Gui's research integrates genomics, transcriptomics, proteomics and other multi-omics approaches to identify genetic biomarkers and biological pathways that contribute to neuropsychiatric disorders and other complex diseases. His work investigates gene-environment interactions associated with opioid use disorder, depression, suicidality and severe mental illness while developing ancestry-informed polygenic risk models that improve prediction across diverse populations. He also studies adverse drug reactions and treatment response to support more personalized approaches to psychiatric care. In collaboration with multidisciplinary research teams, Dr. Gui applies advanced statistical genetics and bioinformatics methods to large-scale population datasets to advance precision psychiatry and reduce health disparities.

Dr. Gui continues to collaborate with investigators across Henry Ford Health, Michigan State University and national research networks to translate genomic discoveries into clinically meaningful applications. His long-term goal is to advance precision medicine by improving risk prediction, treatment selection and health equity for individuals affected by psychiatric and substance use disorders.

Research Interests

• Statistical genetics
• Psychiatric genetics
• Precision psychiatry
• Multi-omics
• Mental health conditions
• Pharmacogenomics
• Health disparities

Email: HGui1@hfhs.org