Kimberley J Woodcroft, PhD

Henry Ford Content Links
Biostatistics & Research Epidemiology

Biography

• HBSc, Pharmacology, University of Western Ontario, London, Canada 1987
• PhD, Pharmacology, University of Western Ontario, London, Canada 1993
• Post-Doc, Molecular Toxicology, Wayne State University, Detroit, MI 1994-1999
• MPH, Epidemiology, University of Michigan, Ann Arbor, MI 2006

Selected Publications

• Zangar RC, Woodcroft KJ, Kocarek TA and Novak RF (1995) Xenobiotic-enhanced expression of cytochrome P450 2E1 and 2B1/2B2 in primary cultured rat hepatocytes. Drug Metab. Dispos. 23: 681-687.
• Zangar RC, Woodcroft KJ and Novak RF (1996) Differential effects of ciprofibrate on renal and hepatic cytochrome P450 2E1 expression. Toxicol. Appl. Pharmacol. 141: 110-116.
  
• Woodcroft KJ, Webb CD, Yao M, Weedon AC and Bend JR (1997) Metabolism of the cytochrome P450 mechanism-based inhibitor N-benzyl-1-aminobenzotriazole to products that covalently bind with protein in guinea pig liver and lung microsomes: comparative study with 1-aminobenzotriazole. Chem. Res. Toxicol. 10: 589-599.
  
• Woodcroft KJ and Novak RF (1997) Insulin effects on CYP2E1, 2B, 3A, and 4A expression in primary cultured rat hepatocytes. Chem.-Biol. Interact. 107: 75-91.
• Woodcroft KJ and Novak RF (1998) Xenobiotic-enhanced expression of cytochromes P450 2E1 and 2B in primary cultured rat hepatocytes. Drug Metab. Dispos. 26: 372-378.
• Woodcroft KJ and Novak RF (1999) Insulin differentially affects xenobiotic-enhanced CYP2E1, 2B, 3A and 4A expression in primary cultured rat hepatocytes. J. Pharmacol. Exp. Ther. 289: 1121-1127.
• Woodcroft KJ and Novak RF (1999) The role of phosphatidylinositol 3-kinase, SRC kinase, and protein kinase A signalling pathways in insulin and glucagon regulation of CYP2E1 expression. Biochem. Biophys. Res. Commun. 266: 304-307.
• Novak RF and Woodcroft KJ (2000) The alcohol-inducible form of cytochrome P450 (CYP2E1): role in toxicology and regulation of expression. Arch. Pharm. Res. 23: 267-282.
• Starcevic SL, Bortolin S, Woodcroft KJ and Novak RF (2001) Kepone (chlordecone) disrupts adherens junctions in human breast epithelial cells cultured on Matrigel. In Vivo 15: 289-294.
• Woodcroft KJ, Hafner MS and Novak RF (2002) Insulin signaling in the transcriptional and posttranscriptional regulation of CYP2E1 expression. Hepatology 35: 263-273.
• Kim SK, Woodcroft KJ and Novak RF (2003) Insulin and glucagon regulation of glutathione S-transferase expression in primary cultured rat hepatocytes. J Pharmacol Exp Ther, 305:353-361.
• Kim SK, Woodcroft KJ, Kim SG and Novak RF (2003) Insulin and glucagon signaling in regulation of microsomal epoxide hydrolase expression in primary cultured rat hepatocytes. Drug Metab Dispos, 31:1260-1268.
• Abdelmegeed MA, Kim SK, Woodcroft KJ and Novak RF (2004) Acetoacetate activation of Erk1/2 and p38 MAPK in primary cultured rat hepatocytes: role of oxidative stress. J Pharmacol Exp Ther, 310:728-736.
• Kim SK, Woodcroft KJ, Khodadadeh SS and Novak RF (2004) Insulin signaling in regulation of ?-glutamylcysteine ligase catalytic subunit in primary cultured rat hepatocytes. J Pharmacol Exp Ther, 311:99-108.
• Abdelmegeed MA, Carruthers NJ, Woodcroft KJ, Kim SK, and Novak RF (2005) Acetoacetate induces cytochrome P450 (CYP) 2E1 protein and suppresses CYP2E1 mRNA in primary cultured rat hepatocytes. J Pharmacol Exp Ther, 315:203-213.
• Kim SK, Woodcroft KJ, Oh SJ, Abdelmegeed MA and Novak RF (2005) Role of mechanical and redox stress in activation of mitogen activated protein kinases in primary cultured rat hepatocytes. Biochem Pharmacol, 70:1785-1795.
• Chen X, Woodcroft KJ, Polymorphisms in Metabolic Genes CYP1A1 and GSTM1 and Changes in Maternal Smoking During Pregnancy. Nic Tob Res. In press