Michigan HIV Consultation Program

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The Michigan HIV Consultation Program has been established to answer questions from Michigan health care professionals regarding:

 

HIV Alert

A study, which looked at babies born to 11,558 HIV-infected women in Botswana, showed that 0.9% of babies (4 of 426) whose mothers became pregnant while taking dolutegravir had a neural tube defect, compared with 0.1% of babies (14 of 11,173) whose mothers took other HIV medicines. These cases have not yet been fully investigated. Final results are expected in about a year.
“Neural tube defects are birth defects of the brain, spine, or spinal cord. They happen very early in pregnancy, often before a woman even knows that she is pregnant. The two most common neural tube defects are spina bifida and anencephaly.”

The question arises on whether this is a Integrase class effect or just confined to Dolutegravir. Raltegravir has been FDA approved since 2007 and we are unaware of similar risk. Bictegravir has only been recently approved and has limited data in pregnant women.

Trogarzo™ (ibalizumab-uiyk) Injection, the First HIV-1 Inhibitor and Long-Acting Monoclonal Antibody for Multidrug Resistant HIV-1

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