Provider Resources

Questions submitted via this site will be answered within 24-48 hours. For urgent questions a 24 hour consultation line is available, call (313) 575-0332

HIV disease management

Development of HIV disease encompasses the acquisition of Human Immunodeficiency Virus (HIV) infection leading to a patient to become HIV-seropositive or asymptomatic infection. Patients may remain with chronic infection and mostly asymptomatic for several years.

Subsequent emergence of symptomatic HIV infection with clinical signs and symptoms leads to HIV disease and without antiretroviral treatment to the development of Acquired Immunodeficiency Syndrome (AIDS).

AIDS is defined as the depletion of CD4 T cell counts below 200 cells/µL and/or the presence of AIDS defining illnesses.

Related resources:

HIV drug-drug interactions

Antiretroviral agents interact with many other commonly prescribed medications and several alternative or complementary therapies. These interactions can lead to either sub- or supra-therapeutic levels of the interacting drugs which can lead to virologic failure, drug toxicity, and ineffective treatment for other comorbidities. Some drug interactions can be life threatening.

Related resources:

HIV occupational post-exposure prophylaxis (PEP)

PEP relates to the clinical and medical management of HIV negative patients who have been exposed to body fluids or other biological material from people with known or suspected HIV infection with consequent risk for transmission of HIV.

The current management guidelines following exposure of body fluids or other biological material from people with HIV infection include assessment of the risk, necessary testing, appropriate use of antiretroviral therapy, and clinical follow up for persons exposed to HIV infected material.

Related resources:

HIV non-occupational post exposure prophylaxis (nPEP)

HIV nPEP is a preventive treatment strategy that may reduce, but not eliminate, the possibility of becoming infected with HIV among individuals who have experienced high risk exposures such as:

  • Unprotected vaginal or anal sex with a partner known to be (or possibly) HIV positive
  • Sharing injecting drug use equipment
  • Sexual assault

nPEP involves taking antiretroviral medications as soon as possible after exposure.

Related resources:

HIV pre-exposure prophylaxis (PrEP)

PrEP represents the clinical management recommendations for patients who are HIV negative but are at high risk for acquiring HIV infection and will likely benefit from prophylaxis with antiretroviral agents.

The guidelines provide the approach to assessing patients at high risk for HIV acquisition, antiretroviral therapy, clinical monitoring and strategies to reduce HIV acquisition.

Related resources:

Perinatal HIV treatment

The prevention of mother-to-child transmission of HIV infection (HIV-infected mother to unborn child) during the perinatal period is key to preventing and possibly eliminating pediatric HIV disease. First and third trimester HIV testing should be provided to all pregnant women.

The guidelines discuss preconception counseling and care of HIV positive women, initiation of antiretroviral therapy in HIV positive pregnant women, antepartum care during the pregnancy, intrapartum care at delivery, and postpartum care of both the mother and HIV-exposed neonate.

Related resources:

Questions submitted via this site will be answered within 24-48 hours. For urgent questions a 24 hour consultation line is available, call (313) 575-0332

Request a consult

Contact the Michigan HIV Consult Program