Discover hundreds of clinical trials for virtually all types of cancer.
Brain cancer chemotherapy uses powerful drugs to target tumors in the brain. These drugs:
All brain cancer chemotherapy has the same goal -- to destroy tumors by disrupting specific cell mechanisms that control tumor growth or multiplication. As part of your personalized treatment plan, you may receive brain tumor chemotherapy alone or in conjunction with other treatments, such as surgery or radiation therapy. At Henry Ford, we employ novel chemotherapy techniques with delivery methods designed to minimize toxicity and side effects.
There are a number of drugs used in brain tumor chemotherapy, including:
In addition, our brain tumor specialists participate in ongoing clinical trials that explore the effectiveness of specific chemotherapy drugs.
Targeted cancer therapies interfere with cancer cell division (proliferation) and spread in different ways. Many of these therapies focus on proteins that are involved in cell signaling pathways, which form a complex communication system that governs basic cellular functions and activities, such as cell division, cell movement, cell responses to specific external stimuli, and even cell death. Targeted therapies of various kinds can:
By focusing on molecular and cellular changes that are specific to cancer, targeted cancer therapies may be more effective than other types of treatment and less harmful to normal cells.Targeted cancer therapies are being studied for use alone, in combination with other targeted therapies, and in combination with other cancer treatments, such as chemotherapy.
Every patient’s brain tumor undergoes a special analysis: brain tumor typing. The genetic and pathological testing of your brain tumor allows us to find the right treatment for you.
MGMT (O(6)-methylguanine-DNA methyltransferase) and temozolomide:
Temodar (temozolomide) has been used for decades to treat people who have a glioblastoma multiforme (GBM). However, research has shown that only 40 percent of people respond to Temodar. Given that GBM is an aggressive tumor, the prognosis does not provide time for trial-and-error treatment. To increase the effectiveness of treatment, our team conducts genetic studies:
With any treatment, there is the potential for side effects, which can vary depending on the type of therapies you receive. While everyone responds differently, some common side effects of chemotherapy include:
In addition to these, people undergoing brain tumor treatment have noticed other issues involving concentration and memory, which are sometimes collectively referred to as “chemo brain.” Depending on the person, it may be temporary or last for years, seriously affecting quality of life. However, chemo brain is still poorly understood, and the name itself may not be accurate, given that other factors -- such as the brain tumor itself, other medical conditions, sleep issues, nutritional deficiencies, stress or age -- can also cause these types of cognitive issues. At the Hermelin Brain Tumor Center, we work with neuro-psychologists to assess neuro-cognitive challenges and to create an individualized treatment plan to increase memory and focus.
Your Hermelin Brain Tumor Center team will review your personalized treatment plan with you and discuss possible side effects before brain chemotherapy treatment begins, so that you can make informed decisions about your brain tumor care.