Types of chemotherapy drugs
There are a number of drugs used for brain cancer chemotherapy, including:
- Alkylating agents: Alkylating agents work directly on DNA to prevent cancer cells from reproducing. Nitrosoureas, a type of alkylating agent, can cross the blood-brain barrier and interfere with enzymes that help repair DNA.
- Antimetabolites: Antimetabolites are a class of drugs that interfere with DNA and RNA growth.
- Mitotic inhibitors: Mitotic inhibitors are plant alkaloids and other compounds derived from natural products. They can inhibit or stop enzymes from making proteins needed for reproduction of cancer cells.
In addition, our brain tumor specialists participate in ongoing brain cancer clinical trials that explore the effectiveness of specific chemotherapy drugs
Tailored brain cancer chemotherapy
At Henry Ford, each brain tumor undergoes a special analysis called brain tumor typing. This genetic and pathological testing of the tumor in your brain allows us to find the right treatment for you.
One example is Temodar (temozolomide), a chemotherapy drug used to treat glioblastoma multiforme (GBM) but only effective 40 percent of the time. Given GBM’s aggressiveness, there’s no time for a trial-and-error approach to determine if it’s working or not.
Instead, our team looks at the connection to a gene feature called MGMT (O(6)-methylguanine-DNA methyltransferase) as a way to predict who will respond:
- We analyze whether a molecular “switch” on the gene known as MGMT is active or inactive. MGMT is a DNA repair marker that allows cells damaged by cancer to repair themselves.
- Unfortunately, this built-in ability to repair cells also makes cancer cells resistant to the beneficial effects of radiation therapy and chemotherapy.
- Research has shown that a person whose MGMT switch is “off” has a significantly greater chance of responding positively to a course of treatment that includes Temodar.
- This advanced strategy also allows us to identify people with tumor resistance to Temodar sooner.
Brain cancer chemotherapy side effects
With any cancer treatment, there is the potential for side effects, which can vary depending on the type of therapies you receive.
Your team will review your treatment plan with you and discuss possible side effects before chemotherapy begins. That way, you can make informed decisions about your care. We also provide a full range of brain tumor support to maintain your quality of life.
While everyone responds differently, some common chemotherapy side effects include:
In addition, people undergoing brain tumor chemotherapy have noticed issues with concentration and memory, sometimes collectively called “chemo brain.” Depending on the person, it may be temporary or last for years, seriously affecting quality of life.
Chemo brain is still poorly understood, and the name itself may not be accurate, given that other factors — the tumor itself, other medical conditions, etc. — can cause cognitive issues. We work with neuro-psychologists to assess cognitive challenges and create an individualized plan to increase memory and focus.
Other brain cancer drugs: targeted therapy
Targeted cancer therapies block the growth and spread of cancer by interfering with specific molecules involved in tumor growth and progression. By focusing on molecular and cellular changes specific to cancer, targeted cancer therapies may be more effective than other treatments and less harmful to normal cells.
Targeted therapies are being studied for use alone, in combination with other targeted therapies, and in combination with other brain cancer treatments such as chemotherapy. Targeted therapies of various kinds can:
- Stop tumor growth by blocking formation of blood vessels supplying oxygen (example: Avastin®, the only brain cancer targeted therapy currently approved)
- Block signals that tell cancer cells to grow and divide
- Cause cancer cell death by delivering toxic substances directly to cancer cells
Other brain cancer drugs: immunotherapy
Some drugs are used to stimulate a patient's immune system to attack cancer cells. Immunotherapy drugs are currently only used for brain tumors as part of brain cancer clinical trials.